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Dawley Inc oxycodone delivery
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Comparison:

Article Title: Regulation of Gene Expression in Brain Tissues of Rats Repeatedly Treated by the Highly Abused Opioid Agonist, Oxycodone: Microarray Profiling and Gene Mapping Analysis
Article Snippet: .. Behav Pharmacol 14 :121–127 [ PubMed ] Huang L, Edwards SR, Smith MT. (2005) Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague-Dawley rats: influence of streptozotocin-induced diabetes. ..

Drug discovery:

Article Title: Regulation of Gene Expression in Brain Tissues of Rats Repeatedly Treated by the Highly Abused Opioid Agonist, Oxycodone: Microarray Profiling and Gene Mapping Analysis
Article Snippet: .. Behav Pharmacol 14 :121–127 [ PubMed ] Huang L, Edwards SR, Smith MT. (2005) Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague-Dawley rats: influence of streptozotocin-induced diabetes. ..

Article Title: Regulation of Gene Expression in Brain Tissues of Rats Repeatedly Treated by the Highly Abused Opioid Agonist, Oxycodone: Microarray Profiling and Gene Mapping Analysis
Article Snippet: .. Drug Metab Dispos 34 :1624–1631 [ PubMed ] Chan S, Edwards SR, Wyse BD, Smith MT. (2008) Sex differences in the pharmacokinetics, oxidative metabolism and oral bioavailability of oxycodone in the Sprague-Dawley rat. ..

Article Title: An Oxycodone Conjugate Vaccine Elicits Drug-Specific Antibodies that Reduce Oxycodone Distribution to Brain and Hot-Plate Analgesia
Article Snippet: .. J Med Chem 54 :5221–5228 [ PMC free article ] [ PubMed ] Chan S, Edwards SR, Wyse BD, Smith MT. (2008) Sex differences in the pharmacokinetics, oxidative metabolism and oral bioavailability of oxycodone in the Sprague-Dawley rat . ..

Over Expression:

Article Title: Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy.
Article Snippet: Modulation of P- glycoprotein efflu pump: Induction and activation as a therapeutic strategy - Renata Silva, Vânia Vilas-Boas, Helena Carmo, Ricardo Jorge DinisOliveira, Félix Carvalho, Maria de Lourdes Bastos, Fernando Remião PII: S0163-7258(14)00213-7 DOI: doi: 10.1016/j.pharmthera.2014.11.013 Reference: JPT 6738 To appear in: Pharmacology and Therapeutics Please cite this article as: Silva, R., Vilas-Boas, V., Carmo, H., Dinis-Oliveira, R.J., Carvalho, F., de Lourdes Bastos, M. & Remião, F., Modulation of P glycoprotein efflux pump: Induction and activation as a therapeutic strategy, Pharmacology and Therapeutics (2014), doi: 10.1016/j.pharmthera.2014.11.013 This is a PDF file of an unedited manuscript that has been accepted for publication.. As a service to our customers we are providing this early version of the manuscript.. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form.

other:

Article Title: Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic Wistar rats.
Article Snippet: Pharmacokinetic factors likely contribute at least in part to these between-strain differences, as previous work by our laboratory showed that systemic exposure to oxycodone at 3 weeks post-STZ administration in adult male Dark Agouti rats was only ~60% of that in a corresponding group of STZ-diabetic Sprague-Dawley rats [87].

Produced:

Article Title: Interactions of pain and opioids on conditioned place preference in rodents.
Article Snippet: Rationale Opioid analgesics are the most effective medications used for the treatment of pain, however there are significant risks associated with repeated opioid use including opioid misuse and opioid use disorder development.. Chronic pain affects millions of adults in the United States, and opioid misuse is often comorbid with pain conditions in individuals who are repeatedly treated with opioids.. In addition to providing pain relief, opioids produce rewarding effects, but in chronic pain states, reward processing can become dysregulated.



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